职称/职务

教授

研究方向

天然药物化学，有机合成方法学

邮箱

guozheng.huang@ahut.edu.cn;

guozheng.huang@yahoo.com

学习工作经历

2020.09 –        安徽工业大学化学bat365官网登录入口，教授；

2016.12 – 2020.08 中国科学院新疆理化所，研究员；

2016.07 – 2016.11 中国科学院新疆理化所，副研究员；

2015.06 – 2016.06 上海师范大学生命与环境科学学院，讲师；

2012.07 – 2015.05 德国维尔茨堡大学药物化学与食品化学学院，博士研究生，药物化学专业；

2011.11 – 2012.06 德国雷根斯堡大学药学系，博士研究生，药物化学专业；

2004.09 – 2007.07 中国科学院研究生院，新疆理化技术研究所，硕士研究生，有机化学专业

主要科研项目及成果

主要围绕天然产物，开展分离纯化，结构改造和药理学研究。代表性工作有：(1)通过对中国传统中药吴茱萸的活性成分——吴茱萸碱的结构修饰，发现了一个丁酰胆碱酯酶抑制剂，并具有神经保护作用；(2)发现了一种简单快速地制备吴茱萸次碱及其类似物的合成方法；(3)在化学上首次实现了从水飞蓟素到次大风子素的有效转化方法，并对水飞蓟素进行衍生化，得到的次大风素类化合物有较好的抗癌效果；(4)合作开展了新疆一枝蒿中的特有的倍半萜生物碱——一枝蒿碱G及其相关异构体的全合成；(5)合作开展了药用蕨类植物的活性成分分离，结构改造及活性研究，得到了抗癌活性较好的先导化合物。迄今发表各类科研论文55篇，其中自2017年独立工作以来发表论文45篇。相关工作发表于Organic Letters，European Journal of Medicinal Chemistry，Bioorganic Chemistry，Phytomedicine，Current Topics in Medicinal Chemistry，ACS Chemical Neuroscience，Bioorganic & Medicinal Chemistry，Journal of Chromatography B，Phytochemistry Letters，Natural Product Research等期刊。申请发明专利15项, 其中9项已经获得专利授权。参编图书1部。目前正在开展天然产物的结构改造和药理学研究。主要的研究兴趣包括天然产物的分离、结构修饰及活性研究, 新药合成, 有机合成方法学。2016年入选国家级高层次人才引进计划，2020年入选马鞍山市“龙马工程”高层次人才。目前主要的研究包括天然产物的分离、结构修饰及活性研究，新药合成，有机合成方法学。

近5年来主要期刊论文

1. Zi Liu, Chenlu Xia, Nina Wang, Jianguo Cao, Guozheng Huang*, Liang Ma*. Synthesis and evaluation of piperazine-tethered derivatives of alepterolic acid as anti-cancer agents. Chemistry & Biodiversity, 2023, 20, e202300208. https://doi.org/10.1002/cbdv.202300208

2. Baoxiang Wu, Xian-Yong Wei*, Nina Wang, Chenlu Xia, Rongrong Bao, Jianguo Cao, Zhi-Min Zong, Zi Liu, Liang Ma*, Guozheng Huang*. Synthesis and antiproliferative evaluation of phenylalkylamino-containing alepterolic acid derivatives. Journal of Molecular Structure, 2023, 1284, 135358 https://doi.org/10.1016/j.molstruc.2023.135358

3. Xiaoxiao Pei ¹, Zeyi Zhang ¹, Nina Wang, Guozheng Huang*, Xiaoran Min, Yanzi Yang *, Jianguo Cao*. Onychiol B attenuates lipopolysaccharide-induced inflammation via MAPK/NF-κB pathways and acute lung injury in vivo. Bioorganic Chemistry, 2023, 132, 106351. https://doi.org/10.1016/j.bioorg.2023.106351

4. Tianju Jiang, Xiling Dai, Ting Gao, Lili Wang, Fan Yang, Yu Zhang, Nina Wang, Guozheng Huang*, Jianguo Cao *. Ancepsone A, a new cheilanthane sesterterpene from Aleuritopteris anceps. Tetrahedron Letters, 2022, 100, 153869. https://doi.org/10.1016/j.tetlet.2022.153869

5. Huanwu Hong, Siyue Lou, Fanli Zheng, Hang Gao, Nina Wang, Shasha Tian, Guozheng Huang*, Huajun Zhao*. Hydnocarpin D attenuates lipopolysaccharide-1 induced acute lung injury via MAPK/NF-κB and Keap1/Nrf2/HO-1 pathway. Phytomedicine, 2022, 101, 154143. https://doi.org/10.1016/j.phymed.2022.154143

6. Xin Zhang ¹, Tingting Yang ¹, Xin Jin, Kaige Lin, Xiling Dai, Ting Gao, Guozheng Huang*, Minghui Fan, Liang Ma, Zi Liu*, Jianguo Cao*. Synthesis and biological evaluation of cytotoxic activity of novel podophyllotoxin derivatives incorporating piperazinyl-cinnamic amide moieties. Bioorganic Chemistry, 2022, 123, 105761. https://doi.org/10.1016/j.bioorg.2022.105761

7. Liang Ma, Xiaojing Xuan, Minghui Fan, Yumeng Zhang, Guozan Yuan, Guozheng Huang, Zi Liu*. A novel 8-hydroxyquinoline derivative induces breast cancer cell death through paraptosis and apoptosis. Apoptosis, 2022, 27, 577–589. https://doi.org/10.1007/s10495-022-01737-w

8. Junping Chen, Xiling Dai, Can Jiang, Yuxi Fu, Tianju Jiang, Liping Tang, Linrui Wang, Quanxi Wang, Guozheng Huang*, Jianguo Cao*. One new protocatechuic acid methyl ester and one pair of enantiomeric dihydroflavones isolated from Phymatopteris hastata. Phytochemistry Letters, 2021, 43, 130-134. https://doi.org/10.1016/j.phytol.2021.03.025 

9. Siyue Lou, Huanwu Hong, Liwaliding Maihesuti, Hang Gao, Zhihui Zhu, Lili Xu, Shasha Tian, Guoyin Kai, Guozheng Huang*, Huajun Zhao*. Inhibitory effect of hydnocarpin D on T cell acute lymphoblastic leukemia via induction of ferroptosis-conjugated autophagy. Experimental Biology and Medicine, 2021, 246(13), 1541-1553. https://doi.org/10.1177/15353702211004870

10. Liwaliding Maihesuti, Hongwei Gao, Qi Wang, Jianguo Cao, Haji Akber Aisa*, Guozheng Huang*. Structural modification of sylibin to derivatives of sylibin/hydnocarpin D/silandrin, and biological evaluation of their anticancer activities. Current Topics in Medicinal Chemistry, 2021, 21(15), 1398-1417. ttps://doi.org/10.2174/1568026621666210701142826

11. Can Jiang, Junping Chen, Xiling Dai, Qi Wang, Jianguo Cao*, Guozheng Huang*. ent-Pimaradiene and cyathane diterpenes from Aleuritopteris albofusca. Phytochemistry Letters, 2020, 40, 10–14. https://doi.org/10.1016/j.phytol.2020.09.008

12. Liwaliding Maihesuti, Junjie Yu, Qi Wang, Jianguo Cao*, Guozheng Huang*. Synthesis and anticancer evaluation of amido-derivative of hydnocarpin D. Chinese Journal of Organic Chemistry, 2020, 40 (9), 2764–2771. https://dx.doi.org/10.6023/cjoc202004033

13. Ying Li, Wendian Li, Jiangyan Tian, Guozheng Huang*, Hui Lv*. Nickel-catalyzed asymmetric addition of aromatic halides to ketones: highly enantioselective synthesis of chiral 2,3-dihydrobenzofurans containing a tertiary alcohol. Organic Letters, 2020, 22(14), 5553–5557. https://dx.doi.org/10.1021/acs.orglett.0c01612

14. Sheng Zhang, Niping Feng, Jinwen Huang, Minglong Wang, Lei Zhang, Junjie Yu, Xiling Dai, Jianguo Cao*, Guozheng Huang*. Incorporation of amino moiety to alepterolic acid improve activity against cancer cell lines: synthesis and biological evaluation. Bioorganic Chemistry, 2020, 98, 103756. https://doi.org/10.1016/j.bioorg.2020.103756 

15. Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao*, Jingshan Shen. Biological activities of artemisinin derivatives beyond malaria. Current Topics in Medicinal Chemistry, 2019, 19(3), 205–222. https://doi.org/10.2174/1568026619666190122144217

参编图书

1. Chapter 7 “Anti-cancer hybrids”. Qingjie Zhao, Guozheng Huang*, in the book “Design of Hybrid Molecules for Drug Development”, edited by Michael Decker, published by Elsevier. 2017. ISBN: 978-0-08-101011-2

http://doi.org/10.1016/B978-0-08-101011-2.00007-6